¹¹C-Methionine PET for Identification of Pediatric High-Grade Glioma Recurrence.

ABSTRACT: Differentiating tumor recurrence or progression from pseudoprogression during surveillance of pediatric high-grade gliomas (PHGGs) using MRI, the primary imaging modality for evaluation of brain tumors, can be challenging. The aim of this study was to evaluate whether ¹¹C-methionine PET, a molecular imaging technique that detects functionally active tumors, is useful for further evaluating MRI changes concerning for tumor recurrence during routine surveillance. Methods : Using ¹¹C-methionine PET during follow-up visits, we evaluated 27 lesions in 26 patients with new or worsening MRI abnormalities for whom tumor recurrence was of concern. We performed quantitative and qualitative assessments of both ¹¹C-methionine PET and MRI data to predict t

SUBMITTER: Bag AK 

PROVIDER: S-EPMC9051591 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature