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Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage.

ABSTRACT: A one-pot synthesis, initiated by a copper salt with inorganic (NH₄)₂CO₃ as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via α-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.

SUBMITTER: Huang J

PROVIDER: S-EPMC9051655 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage.

Huang Jiangkun J Luo Lan L Xing Naiguo N Gu Linghui L Li Chen C Han Qiao Q Zheng Shilong S He Ling L

RSC advances 20200406 23

A one-pot synthesis, initiated by a copper salt with inorganic (NH4)2CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via α-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility. ...[more]

PMID: 35492973

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