New diterpenoid quinones derived from Salvia miltiorrhiza and their cytotoxic and neuroprotective activities.

ABSTRACT: One new tanshinone derivative, which possesses an unusual 6/6/5/6 fused-ring skeleton system (1), together with four new five-membered lactone benzohexa-membered ring compounds (2, 3, 4A and 4B), and three new carboxyl substituted 5,5-spiroketal compounds (5-7), were isolated from the dried rhizomes of Salvia miltiorrhiza. The structures of these compounds were determined by multiple spectral analyses (UV, IR, NMR, and HR-ESI-MS). In addition, the absolute configurations were established by X-ray diffraction experiments, calculated and experimental circular dichroism spectra. Evaluation of antitumor activity showed that 1 had strong cytotoxicity to tumor-repopulating cells (TRCs) with an IC₅₀ value of 2.83 μM. In the evaluation of neuroprotective activity, 4A and 6 showed

SUBMITTER: Yin ZK 

PROVIDER: S-EPMC9051908 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature