STAG2 Protein Expression in Non-muscle-invasive Bladder Cancer: Associations with Sex, Genomic and Transcriptomic Changes, and Clinical Outcomes.

ABSTRACT:

Background

Mutations in STAG2 cause complete loss of STAG2 protein in approximately one-third of non-muscle-invasive bladder cancers (NMIBCs). STAG2 protein expression is easily determined via immunohistochemistry (IHC) and published data suggest that loss of STAG2 expression is a good prognostic indicator in NMIBC.

Objective

To confirm the relationship between STAG2 protein expression and clinical outcomes and tumour characteristics in NMIBC.

Design setting and participants

IHC was used to determine STAG2 expression in 748 incident urothelial bladder cancers (UBCs) and recurrence-free, progression-free, and disease-specific survival were compared for patients with and without STAG2 loss. Exome and RNA sequencing were used to explore links between STAG2

SUBMITTER: Gordon NS 

PROVIDER: S-EPMC9051973 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature