Household Secondary Attack Rates of SARS-CoV-2 by Variant and Vaccination Status: An Updated Systematic Review and Meta-analysis.

ABSTRACT:

Importance

An overall household secondary attack rate (SAR) of 18.9% (95% CI, 16.2%-22.0%) through June 17, 2021 was previously reported for SARS-CoV-2. Emerging variants of concern and increased vaccination have affected transmission rates.

Objective

To evaluate how reported household SARs changed over time and whether SARs varied by viral variant and index case and contact vaccination status.

Data sources

PubMed and medRxiv from June 18, 2021, through March 8, 2022, and reference lists of eligible articles. Preprints were included.

Study selection

Articles with original data reporting the number of infected and total number of household contacts. Search terms included SARS-CoV-2, COVID-19, variant, vaccination, secondary attack rate, secondary infection rate,

SUBMITTER: Madewell ZJ 

PROVIDER: S-EPMC9051991 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature