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An approach to new chiral bicyclic imines and amines via Horner-Wadsworth-Emmons reaction.

ABSTRACT: New chiral bicyclic imines, enamines and amines were prepared via Horner-Wadsworth-Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, high selectivity, and broad substrate scope are the main advantages of the presented methodology.

SUBMITTER: Iwanejko J

PROVIDER: S-EPMC9052066 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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An approach to new chiral bicyclic imines and amines via Horner-Wadsworth-Emmons reaction.

Iwanejko Jakub J Sowiński Mateusz M Wojaczyńska Elżbieta E Olszewski Tomasz K TK Górecki Marcin M

RSC advances 20200409 25

New chiral bicyclic imines, enamines and amines were prepared via Horner-Wadsworth-Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, high selectivity, and broad substrate scope are the main advantages of the presented methodology. ...[more]

PMID: 35497115

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