Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach.

ABSTRACT: Drug-induced nephrotoxicity remains a common problem after exposure to medications and diagnostic agents, which may be heightened in the kidney microenvironment and deteriorate kidney function. In this study, the toxic effects of fourteen marked drugs with the individual chemical structure were evaluated in kidney cells. The quantitative structure-activity relationship (QSAR) approach was employed to investigate the potential structural descriptors of each drug-related to their toxic effects. The most reasonable equation of the QSAR model displayed that the estimated regression coefficients such as the number of ring assemblies, three-membered rings, and six-membered rings were strongly related to toxic effects on renal cells. Meanwhile, the chemical properties of the tested compounds incl

SUBMITTER: Huang HJ 

PROVIDER: S-EPMC9052077 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature