Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery.

ABSTRACT: We report herein the synthesis of a novel photocleavable crosslinker, 4-formylphenyl 4-((4-formylphenoxy)methyl)-3-nitrobenzoate (CHO-ONB-CHO) and its joining with amine-based polysaccharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive (ONB-chitosan) hydrogel having UV- and pH-responsive sites. The detailed mechanism for the formation of CHO-ONB-CHO and ONB-chitosan hydrogel is proposed. The (CHO-ONB-CHO) crosslinker was characterized using ¹H-NMR, LCMS and UV-visible spectroscopy. The dual responsive hydrogel is characterized by FTIR, SEM, XRD, DSC and TGA. The crosslinked hydrogel displayed mechanical robustness with a storage modulus of about 1741 pa. The pH-responsiveness of the hydrogel was studied via equilibrium swelling studies i

SUBMITTER: Nisar S 

PROVIDER: S-EPMC9052095 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature