Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Importance

Tumor histological factors that predict immunotherapy response in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) are not well defined.

Objective

To investigate the association between tumor grade and immunotherapy response in patients with recurrent or metastatic mucosal HNSCC.

Design, setting, and participants

In this retrospective cohort study, the medical records of 60 patients with recurrent or metastatic mucosal HNSCC treated with immune checkpoint inhibitors at Johns Hopkins Hospital between July 1, 2015, and January 22, 2020, were reviewed.

Exposures

High-grade tumors (HGTs) vs low-grade tumors (LGTs) in recurrent or metastatic HNSCC.

Main outcomes and measures

Patients were divided into 2 groups: th

SUBMITTER: Alkhatib HH 

PROVIDER: S-EPMC9052109 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature