Investigating partitioning of free versus macrocycle bound guest into a model POPC lipid bilayer.

ABSTRACT: We report on the permeation of free and macrocycle-bound avobenzone across a POPC lipid bilayer through combined neutron reflectometry experiments and molecular dynamics simulations. Results indicate that the p-phosphonated calix[8]arene macrocycle limits the avobenzone penetration into the upper leaflet of the membrane. Hence, it could serve as a useful vehicle for safer formulations.

SUBMITTER: Kumari H 

PROVIDER: S-EPMC9052308 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature