Differential effects of subchronic acrylonitrile exposure on hydrogen sulfide levels in rat blood, brain, and liver.

ABSTRACT:

Background

Hydrogen sulfide (H₂S), as the third gasotransmitter participates in both cellular physiological and pathological processes, including chemical-induced injuries. We recently reported acute acrylonitrile (AN) treatment inhibited endogenous H₂S biosynthesis pathway in rat and astrocyte models. However, there is still no evidence to address the correlation between endogenous H₂S and sub-chronic AN exposure.

Objectives

This study aims to explore the modulatory effects of prolonged AN exposure on endogenous H2S levels and its biosynthetic enzymes in rat blood, brain and liver.

Methods

A total of 50 male Sprague-Dawley rats were randomly divided into 5 groups, including the control group and AN-treated groups at dosages of 6.25, 1

SUBMITTER: Yang B 

PROVIDER: S-EPMC9052317 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature