Cerium oxide nanoparticles attenuate the renal injury induced by cadmium chloride via improvement of the NBN and Nrf2 gene expressions in rats.

ABSTRACT:

Background

Cadmium (Cd) is a highly toxic heavy metal that adversely affects both human and animal health. Chronic cadmium exposure causes serious kidney damage. The current study investigated the protective role of cerium oxide nanoparticles (CeO₂NPs) against cadmium chloride (CdCl₂)-induced renal injury.

Method

One hundred and twenty male albino rats were divided into 6 equal groups. Group (C): considered as control group which was given distilled water orally. Group (NC_.1 and NC_.5): rats were injected i.p. with nanoceria at a dose of (0.1 and 0.5 mg/kg b.wt), respectively, twice a week for 2 weeks starting at the 15th day of the study. Group (Cd): rats were received CdCl₂ orally (10 mg/kg b.wt) daily for 28 days. Grou

SUBMITTER: Bashandy PhD MM 

PROVIDER: S-EPMC9052319 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature