TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice.

ABSTRACT:

Background

Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the risk of developing cardiovascular disease and neuroinflammation. Events, such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in MS may contribute to the direct or indirect activation of Toll-like receptors (TLRs), specifically TLR4, which is thought to be a major component of this syndrome. Activation of the innate immune response via TLR4 may contribute to this state of chronic inflammation and may be related to the neuroinflammation and neurodegeneration observed in MS. In this study, we investigated the role of TLR4 in the brain mic

SUBMITTER: Obadia N 

PROVIDER: S-EPMC9052472 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature