HOXC6 impacts epithelial-mesenchymal transition and the immune microenvironment through gene transcription in gliomas.

ABSTRACT:

Background

Gliomas are the most common primary malignant tumours of the central nervous system (CNS). To improve the prognosis of glioma, it is necessary to identify molecular markers that may be useful for glioma therapy. HOXC6, an important transcription factor, is involved in multiple cancers. However, the role of HOXC6 in gliomas is not clear.

Methods

Bioinformatic and IHC analyses of collected samples (n = 299) were performed to detect HOXC6 expression and the correlation between HOXC6 expression and clinicopathological features of gliomas. We collected clinical information from 177 to 299 patient samples and estimated the prognostic value of HOXC6. Moreover, cell proliferation assays were performed. We performed Gene Ontology (GO) analysis and gene set enrichment analy

SUBMITTER: Huang H 

PROVIDER: S-EPMC9052479 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature