Thermosensitive core-rigid micelles of monomethoxy poly(ethylene glycol)-deoxy cholic acid.

ABSTRACT:

Background

Thermosensitive micelles with rigid cores that exhibit a reversible lower critical solution temperature at 30-35 °C can be applied for drug delivery.

Method

Hydrophilic monomethoxy poly(ethylene glycol) was conjugated to hydrophobic deoxycholic acid to prepare monomethoxy poly(ethylene glycol)-deoxycholic acid (mPEG-DC). Micelle formation and thermosensitive solution behavior were studied using various methods, including hydrophobic dye solubilization, transmission electron microscopy, dynamic light scattering, turbidity measurement, microcalorimetry, and ¹H-NMR spectroscopy. Drug release from the thermosensitive micelles was demonstrated using estradiol, a model drug.

Results

The mPEG-DC formed micelles with a critical micelle concentration of 0

SUBMITTER: Han JO 

PROVIDER: S-EPMC9052506 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature