Identification of invasion-metastasis associated MiRNAs in gallbladder cancer by bioinformatics and experimental validation.

ABSTRACT:

Background

Recent studies exploring the roles of invasion-metastasis associated miRNAs in gallbladder cancer (GBC) are limited. In the study, we aimed to identify the invasion-metastasis associated miRNAs in GBC by bioinformatics and experimental validation.

Methods

MiRNAs of different expression were identified by comparing GBC tumor samples with different survival from Gene Expression Omnibus database. MiRTarBase was used for identifying the potential target genes of miRNAs. Then, we performed Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. And miRNA-gene and protein-protein interaction (PPI) network were constructed for hub genes evaluation. We further explored and compared miR-642a-3p and miR-145-5p expression i

SUBMITTER: Cao J 

PROVIDER: S-EPMC9052523 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature