Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by impaired pulmonary development which persists into later life. While advances in neonatal care have improved survival rates of premature infants, cases of BPD have been increasing with limited therapeutic options for prevention and treatment. This study was designed to explore the relationship between gestational age (GA), birth weight, and estimated blood cell-type composition in premature infants and to elucidate early epigenetic biomarkers associated with BPD.

Methods

Cord blood DNA from preterm neonates that went on to develop BPD (n = 14) or not (non-BPD, n = 93) was applied to Illumina 450 K methylation arrays. Blood cell-typ

SUBMITTER: Wang X 

PROVIDER: S-EPMC9052529 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature