TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes.

ABSTRACT:

Background

T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level. The analysis of the TCR repertoire with respect to clinical phenotypes can yield novel insights into the etiology and progression of immune-mediated diseases. However, methods for association analysis of the TCR repertoire have not been well developed.

Methods

We introduce an analysis tool, TCR-L, for evaluating the association between the TCR repertoire and disease outcomes. Our approach is developed under a mixed effect modeling, where the fixed effect represents features that can be explicitly extracted from TCR sequences while the random effect

SUBMITTER: Liu M 

PROVIDER: S-EPMC9052542 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature