Indocyanine Green-Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy.

ABSTRACT: Traditional oncology treatment modalities are often associated with a poor therapeutic index. This has driven the development of new targeted treatment modalities, including several based on the conversion of optical light into heat energy (photothermal therapy, PTT) and sound waves (photoacoustic imaging, PA) that can be applied locally. These approaches are especially effective when combined with photoactive nanoparticles that preferentially accumulate in tissues of interest and thereby further increase spatiotemporal resolution. In this study, two clinically-used materials that have proven effective in both PTT and PA - indocyanine green and gold nanoparticles - were combined into a single nanoformulation. These particles, "ICG-AuNP clusters", incorporated high concentrations of both mo

SUBMITTER: Higbee-Dempsey E 

PROVIDER: S-EPMC9052658 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature