Gene expression of fibrinolytic markers in coronary thrombi.

ABSTRACT:

Background

The fibrinolytic system plays an important role in coronary artery atherothrombosis, and especially circulating plasminogen-activator inhibitor (PAI) type 1 (PAI-1) associates with increased mortality, infarct size and heart failure in patients with myocardial infarction (MI). In a cross-sectional study, we aimed to study whether genes encoding tissue plasminogen activator (tPA), urinary-type plasminogen activator (uPA), PAI-1 and PAI-2 are expressed in coronary thrombi from acute ST-elevation MI (STEMI) patients. Any relations to myocardial injury measured by peak troponin T, time from symptom onset to Percutaneous Coronary Intervention (PCI), and to different cell types present in the thrombi were also explored.

Methods

Intracoronary thrombi were aspirated from

SUBMITTER: Nordeng J 

PROVIDER: S-EPMC9052700 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature