Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters.

ABSTRACT: Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and diastereoselectivity of the substitution is attributed to the existence of a bicyclobutonium intermediate.

SUBMITTER: Patel K 

PROVIDER: S-EPMC9052742 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature