Aerobic Photobiocatalysis Enabled by Combining Core-Shell Nanophotoreactors and Native Enzymes.

ABSTRACT: Biocatalysis has become a powerful tool in synthetic chemistry, where enzymes are used to produce highly selective products under mild conditions. Using photocatalytically regenerated cofactors in synergistic combination with enzymes in a cascade fashion offers an efficient synthetic route to produce specific compounds. However, the combination of enzymes and photocatalysts has been limited due to the rapid degradation of the biomaterials by photogenerated reactive oxygen species, which denature and deactivate the enzymatic material. Here, we design core-shell structured porous nano-photoreactors for highly stable and recyclable photobiocatalysis under aerobic conditions. The enzymatic cofactor NAD⁺ from NADH can be efficiently regenerated by the photoactive organosilica core, w

SUBMITTER: Wei W 

PROVIDER: S-EPMC9052756 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature