Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains.

ABSTRACT: SARS-CoV-2 is a highly transmissible and pathogenic coronavirus that first emerged in late 2019 and has since triggered a pandemic of acute respiratory disease named COVID-19 which poses a significant threat to all public health institutions in the absence of specific antiviral treatment. Since the outbreak began in March 2020, India has reported 4.77 lakh Coronavirus deaths, according to the World Health Organization (WHO). The innate RNA interference (RNAi) pathway, on the other hand, allows for the development of nucleic acid-based antiviral drugs in which complementary small interfering RNAs (siRNAs) mediate the post-transcriptional gene silencing (PTGS) of target mRNA. Therefore, in this current study, the potential of RNAi was harnessed to construct siRNA molecules that target the co

SUBMITTER: Madanagopal P 

PROVIDER: S-EPMC9052778 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature