Ontology highlight
ABSTRACT:
SUBMITTER: Bhandari S
PROVIDER: S-EPMC9052938 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
RSC advances 20200424 27
Herein, we report a facile tandem approach for the synthesis of both spiro-oxindole-fused pyrroloindolines and benzofurano-pyrrolidines <i>via</i> a Lewis acid-catalyzed domino ring-opening with concomitant ring annulation using activated spiro-aziridines and heteroarenes. This method offers a new class of novel spiro-fused polycyclic pyrrolidines in a one-pot and sustainable manner with good yields and high diastereoselectivity. In addition, the structure of 3d was confirmed by single X-ray cry ...[more]