Ruthenium carboranyl complexes with 2,2'-bipyridine derivatives for potential bimodal therapy application.

ABSTRACT: Ruthenium complexes of carboranyl ligands offer the possibility of dual action (chemo + radiotherapy) that might result in significant clinical benefits. In that frame, we describe herein the development of ruthenium-carboranyl complexes bearing bipyridyl derivatives with the general formula [3-CO-3,3-{κ²-4,4'-R₂-2,2'-bipy}-closo-3,1,2-RuC₂B₉H₁₁] (R = CH₃, RuCB1 or R = CH₂OH, RuCB2). Both compounds crystallized in the monoclinic system, showing the expected three-legged piano stool structure. The ruthenacarboranes are stable in cell culture media and were tested against two cell lines that have shown favorable clinical responses with BNCT, namely melanoma (A375) and glioblastoma (U87). RuCB1 shows no cytoto

SUBMITTER: Teixeira RG 

PROVIDER: S-EPMC9053089 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature