Sonochemical synthesis of polyoxometalate-stabilized gold nanoparticles for point-of-care determination of acetaminophen levels: preclinical study in an animal model.

ABSTRACT: The aim of this study is the accurate and rapid detection of acetaminophen (AP) for point-of-care (POC) clinical diagnosis. Acetaminophen overdose causes acute liver failure and currently there is a lack of rapid quantitative detection methods for this drug in the emergency room. Here, low-frequency sonication (20 kHz) in the presence of phosphomolybdic acid (PMo₁₂) was used to reduce Au³⁺ to Au⁰ and stabilize the resulting spherical Au⁰ nanoparticles (herein AuNPs). These AuNPs@PMo₁₂ were used as nano-probes for the selective detection of acetaminophen in the presence of other commercial drugs. The optical sensing method we describe is based on the aggregation of AuNPs@PMo₁₂ in the presence of acetaminophen, which produces

SUBMITTER: Bastami TR 

PROVIDER: S-EPMC9053096 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature