Ontology highlight
ABSTRACT:
SUBMITTER: Fuentes GV
PROVIDER: S-EPMC9053171 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Fuentes German V GV Doucet Eric N EN Abraham Alyson A Rodgers Nikki K NK Alonso Felix F Euceda Nelson N Quinones Michael H MH Riascos Penelope A PA Pierre Kristelle K Sarker Nuhash H NH Dhar-Mascareno Manya M Cotlet Mircea M Kisslinger Kim K Camino Fernando F Li Mingxing M Lu Fang F Gao Ruomei R
RSC advances 20200401 29
It is both challenging and desirable to have drug sensitizers released at acidic tumor pH for photodynamic therapy in cancer treatment. A pH-responsive carrier was prepared, in which fumed silica-attached 5,10,15,20-tetrakis(4-trimethylammoniophenyl)porphyrin (TTMAPP) was encapsulated into 1,2-dioleoyl-<i>sn-glycero</i>-3-phosphocholine (DOPC) nanocomposite liposomes. The sizes of agglomerates were determined by dynamic light scattering to be 115 nm for silica and 295 nm for silica-TTMAPP-DOPC l ...[more]