A comparative study of the drying evolution and dried morphology of two globular proteins in de-ionized water solutions.

ABSTRACT: Pattern formation in drying protein droplets continues to attract considerable research attention because it can be linked to specific protein-protein interactions. An extensive study of the drying evolution and the final crack patterns is presented, highlighting the concentration dependence (from 1 to 13 wt%) of two globular proteins, lysozyme (Lys) and bovine serum albumin (BSA), in de-ionized water. The drying evolution starts with a constant contact radius mode and shifts to a mixed mode where both fluid front and contact angle changes. The contact angle monotonically decreases, whereas, the fluid front exhibits two regimes: an initial linear regime and a later non-linear regime. Unlike the linear regime, the non-linear regime is faster for Lys droplets. This results in the formation o

SUBMITTER: Pal A 

PROVIDER: S-EPMC9053175 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature