Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection.

ABSTRACT:

Background

It is estimated that up to 80% of infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are asymptomatic and asymptomatic patients can still effectively transmit the virus and cause disease. While much of the effort has been placed on decoding single nucleotide variation in SARS-CoV-2 genomes, considerably less is known about their transcript variation and any correlation with clinical severity in human hosts, as defined here by the presence or absence of symptoms.

Methods

To assess viral genomic signatures of disease severity, we conducted a systematic characterization of SARS-CoV-2 transcripts and genetic variants in 81 clinical specimens collected from symptomatic and asymptomatic individuals using multi-scale transcriptomic analyses

SUBMITTER: Wong CH 

PROVIDER: S-EPMC9053197 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature