Pan-cancer analysis of the effect of biopsy site on tumor mutational burden observations.

ABSTRACT:

Background

Tumor mutational burden (TMB) has been proposed as a predictive biomarker of response to immunotherapy. Efforts to standardize TMB scores for use in the clinic and to identify the factors that could impact TMB scores are of high importance. However, the biopsy collection site has not been assessed as a factor that may influence TMB scores.

Methods

We examine a real-world cohort comprising 137,771 specimens across 47 tissues in 12 indications profiled by the FoundationOne assay (Foundation Medicine, Cambridge, MA) to assess the prevalence of biopsy sites for each indication and their TMB scores distribution.

Results

We observe a wide variety of biopsy sites from which specimens are sent for genomic testing and show that TMB scores differ in a cancer- and tis

SUBMITTER: Papillon-Cavanagh S 

PROVIDER: S-EPMC9053207 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature