A case report describing the immune response of an infant with congenital heart disease and severe COVID-19.

ABSTRACT:

Background

Children with SARS-CoV-2 infection generally present with milder symptoms or are asymptomatic in comparison with adults, however severe disease occurs in a subset of children. To date, the immune correlates of severe COVID-19 in young children have been poorly characterised.

Methods

We report the kinetics of immune responses in relation to clinical and virological features in an infant with acute severe COVID-19 using high-dimensional flow cytometry and multiplex cytokine analysis.

Results

Systemic cellular and cytokine profiling show an initial increase in neutrophils and monocytes with depletion of lymphoid cell populations (particularly CD8 + T and NK cells) and elevated inflammatory cytokines. Expansion of memory CD4 + T (but not CD8 + T) cells occurred

SUBMITTER: Wurzel D 

PROVIDER: S-EPMC9053208 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature