Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin.

ABSTRACT:

Background

The levels of circulating troponin are principally required in addition to electrocardiograms for the effective diagnosis of acute coronary syndrome. Current standard-of-care troponin assays provide a snapshot or momentary view of the levels due to the requirement of a blood draw. This modality further restricts the number of measurements given the clinical context of the patient. In this communication, we present the development and early validation of non-invasive transdermal monitoring of cardiac troponin-I to detect its elevated state.

Methods

Our device relies on infrared spectroscopic detection of troponin-I through the dermis and is tested in stepwise laboratory, benchtop, and clinical studies. Patients were recruited with suspected acute coronary syndrome.

SUBMITTER: Titus J 

PROVIDER: S-EPMC9053220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature