Spatial structure impacts adaptive therapy by shaping intra-tumoral competition.

ABSTRACT:

Background

Adaptive therapy aims to tackle cancer drug resistance by leveraging resource competition between drug-sensitive and resistant cells. Here, we present a theoretical study of intra-tumoral competition during adaptive therapy, to investigate under which circumstances it will be superior to aggressive treatment.

Methods

We develop and analyse a simple, 2-D, on-lattice, agent-based tumour model in which cells are classified as fully drug-sensitive or resistant. Subsequently, we compare this model to its corresponding non-spatial ordinary differential equation model, and fit it to longitudinal prostate-specific antigen data from 65 prostate cancer patients undergoing intermittent androgen deprivation therapy following biochemical recurrence.

Results

Leveraging t

SUBMITTER: Strobl MAR 

PROVIDER: S-EPMC9053239 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature