Functional brain activity constrained by structural connectivity reveals cohort-specific features for serum neurofilament light chain.

ABSTRACT:

Background

Neuro-axonal brain damage releases neurofilament light chain (NfL) proteins, which enter the blood. Serum NfL has recently emerged as a promising biomarker for grading axonal damage, monitoring treatment responses, and prognosis in neurological diseases. Importantly, serum NfL levels also increase with aging, and the interpretation of serum NfL levels in neurological diseases is incomplete due to lack of a reliable model for age-related variation in serum NfL levels in healthy subjects.

Methods

Graph signal processing (GSP) provides analytical tools, such as graph Fourier transform (GFT), to produce measures from functional dynamics of brain activity constrained by white matter anatomy. Here, we leveraged a set of features using GFT that quantified the coupling be

SUBMITTER: Sihag S 

PROVIDER: S-EPMC9053240 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature