Application of the dual stream model to neurodegenerative disease: Evidence from a multivariate classification tool in primary progressive aphasia.

ABSTRACT:

Background

A clinical diagnosis of primary progressive aphasia relies on behavioral characteristics and patterns of atrophy to determine a variant: logopenic; nonfluent/agrammatic; or semantic. The dual stream model (Hickok & Poeppel, 2000; 2004; 2007; 2015) is a contemporary paradigm that has been applied widely to understand brain-behavior relationships; however, applications to neurodegenerative diseases like primary progressive aphasia are limited.

Aims

The primary aim of this study is to determine if the dual stream model can be applied to a neurodegenerative disease, such as primary progressive aphasia, using both behavioral and neuroimaging data.

Methods & procedures

We analyzed behavioral and neuroimaging data to apply a multivariate classification tool (suppo

SUBMITTER: Keator LM 

PROVIDER: S-EPMC9053317 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature