SO₂F₂-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN).

ABSTRACT: A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9053412 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature