Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.

ABSTRACT:

Background

There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case-control genome-wide association studies have identified variants associated with disease risk, but not progression. The objective of the current study was to identify genetic variants associated with PD progression.

Methods

We analyzed 3 large longitudinal cohorts: Tracking Parkinson's, Oxford Discovery, and the Parkinson's Progression Markers Initiative. We included clinical data for 3364 patients with 12,144 observations (mean follow-up 4.2 years). We used a new method in PD, following a similar approach in Huntington's disease, in which we combined multiple assessments using a principal components analysis to derive scores for composite, motor, and cognitive pr

SUBMITTER: Tan MMX 

PROVIDER: S-EPMC9053517 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature