Alterations of Striatal Subregions in a Prion Protein Gene V180I Mutation Carrier Presented as Frontotemporal Dementia With Parkinsonism.

ABSTRACT:

Objective

To explore the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient resulting from prion protein gene (PRNP) mutation.

Methods

This patient received clinical interviews and underwent neuropsychological assessments, genetic testing, [¹⁸F]-fluorodeoxyglucose positron emission tomography ([¹⁸F]-FDG PET)/MRI, and [¹⁸F]-dihydrotetrabenazine positron emission tomography ([¹⁸F]-DTBZ PET)/CT. Region-of-interest analysis was conducted concerning metabolism, and dopamine transport function between this patient and 12 controls, focusing on the striatum subregions according to the Oxford-GSK-Imanova Striatal Connectivity Atlas.

Results

A 64-year-old man initially p

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9053668 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature