In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps.

ABSTRACT: Adenomatous polyps of the colon are the most common neoplastic polyps. Although most of adenomatous polyps do not show malign transformation, majority of colorectal carcinomas originate from neoplastic polyps. Therefore, understanding of this transformation process would help in both preventive therapies and evaluation of malignancy risks. This study uncovers alterations in gene expressions as potential biomarkers that are revealed by integration of several network-based approaches. In silico analysis performed on a unified microarray cohort, which is covering 150 normal colon and adenomatous polyp samples. Significant gene modules were obtained by a weighted gene co-expression network analysis. Gene modules with similar profiles were mapped to a colon tissue specific functional interactio

SUBMITTER: Isik Z 

PROVIDER: S-EPMC9053805 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature