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Lipofection with estrone-based luminophores featuring aggregation-induced emission properties.

ABSTRACT: In this communication we present the use of a novel class of luminophores with aggregation-induced emission (AIE) properties based on the steroid estrone. These molecules were equipped with cationic residues yielding amphiphiles suitable for lipofection. To this end, self-assembled luminescent structures were formed in aqueous media and mixed with a red-fluorescent protein expressing plasmid, yielding lipoplexes with increased emission intensity. These luminescent lipoplexes were able to efficiently transfect HeLa and HEK 293T cells and were able to be tracked due to the aggregation induced-emission properties.

SUBMITTER: Riebe S

PROVIDER: S-EPMC9054052 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Lipofection with estrone-based luminophores featuring aggregation-induced emission properties.

Riebe Steffen S Zimmermann Alexander A Koch Johannes J Vallet Cecilia C Knauer Shirley K SK Sowa Andrea A Wölper Christoph C Voskuhl Jens J

RSC advances 20200527 33

In this communication we present the use of a novel class of luminophores with aggregation-induced emission (AIE) properties based on the steroid estrone. These molecules were equipped with cationic residues yielding amphiphiles suitable for lipofection. To this end, self-assembled luminescent structures were formed in aqueous media and mixed with a red-fluorescent protein expressing plasmid, yielding lipoplexes with increased emission intensity. These luminescent lipoplexes were able to efficie ...[more]

PMID: 35515436

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