Adrenergic receptors gene polymorphisms and autonomic nervous control of heart and vascular tone.

ABSTRACT: Adrenergic receptors (ARs) are the primary targets of catecholamines released from the sympathetic nerve endings during their activation. ARs play a central role in autonomic nervous system and serve as important targets of widely used drugs. Several ARs gene polymorphisms were found to be associated with cardiovascular disease in previous clinical studies. Although more precise mechanism of the polymorphisms influence on autonomic control of cardiovascular system was studied in many previous physiological studies, their results are not unequivocal. This paper reviews the results of clinical and physiological studies focused on the impact of selected common single nucleotide polymorphisms of ARs genes involved in sympathetic control on cardiovascular system and its control. In summary, man

SUBMITTER: Matuskova L 

PROVIDER: S-EPMC9054179 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature