Hydrocortisone for Preventing Adverse Drug Reactions to Snake Antivenom: A Meta-Analysis.

ABSTRACT:

Objective

Pretreatment with hydrocortisone (prehydrocortisone) has been used to protect against adverse drug reactions (ADRs) following antivenom administration after snakebite. However, controversial results have been reported in studies evaluating its efficacy. Herein, we conducted a meta-analysis to evaluate the effect of prehydrocortisone on the risk of ADRs.

Methods

We conducted a systematic search of PubMed, Embase, and Cochrane for relevant studies on the literature published up to December 6, 2020, with no language restrictions. Premedications, including hydrocortisone with or without other drugs, were compared with placebo or no premedication. Our primary end point was the risk of ADRs, which was reported as the number of patients who developed ADRs divided by the t

SUBMITTER: Feng J 

PROVIDER: S-EPMC9054406 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature