Expression of Matrix Metalloproteinase-7 Predicts Poor Prognosis in Gastric Cancer.

ABSTRACT: To date, no potential markers have been established for predicting prognosis in gastric cancer. Matrix metalloproteinase-7 (MMP-7) has been suggested as a prognostic marker in several cancers. In this study, we aimed to determine the expression of the MMP-7 protein and its polymorphisms in gastric cancer tissues. The association between MMP-7 expression level and clinicopathological characteristics was also evaluated. MMP-7 protein expression and its polymorphisms were investigated in a total of 400 patients using immunohistochemistry and TaqMan SNP genotyping assays. The correlation of MMP-7 expression with clinicopathological characteristics, including tumor location, tumor size, histologic type, lymphatic invasion, vascular invasion, pathological T stage, pathological TNM stage, residua

SUBMITTER: Wattanawongdon W 

PROVIDER: S-EPMC9054443 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature