A new dendrimer series: synthesis, free radical scavenging and protein binding studies.

ABSTRACT: Tri-o-tolyl benzene-1,3,5-tricarboxylate (TOBT (T0)), tri-4-hydroxyphenyl benzene-1,3,5-tricarboxylate (THBT (T1)), and tri-3,5-dihydroxyphenyl benzene-1,3,5-tricarboxylate (TDBT (T2)), a series of 1^st tier dendrimers with a common 1,3,5-benzenetricarbonyl trichloride/trimesoyl chloride (TMC) core, are reported. T0 does not have any replaceable H⁺ on its terminal phenyl group, acting as a branch. T1 has one phenolic -OH at the para position and T2 has two phenolic -OH groups at the 3 and 5 positions of each terminal phenyl group. During synthesis, these -OH groups at the terminal phenyl groups were protected through tert-butyldimethylsilyl chloride (TBDMSCl) assisted with t-BuOK in DCM, THF, indazole, 4-dimethylaminopyridine (DMAP), and ter

SUBMITTER: Makawana D 

PROVIDER: S-EPMC9054494 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature