Preparation of quercetin-nicotinamide cocrystals and their evaluation under in vivo and in vitro conditions.

ABSTRACT: Quercetin is a flavonoid abundant in the plant kingdom. Various types of bioactivities of quercetin have been demonstrated in vitro. Although quercetin has been proposed to exhibit numerous pharmacological benefits, it suffers from low bioavailability on account of its obviously poor solubility in water. Cocrystals have generated interest recently as a way of enhancing the dissolution in vitro and creating relative bioavailability of insoluble medicine. In this study, quercetin-nicotinamide cocrystals were obtained via a solvent evaporation technique. Furthermore, quercetin-nicotinamide cocrystals were characterized via Fourier transform infrared (FI-IR) spectroscopy, X-ray powder diffraction (PXRD), and differential scanning calorimetry (DSC) techniques. Querce

SUBMITTER: Wu N 

PROVIDER: S-EPMC9054514 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature