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Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans.

ABSTRACT: Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. Notably, simple O₂ gas served as an oxidant, without using any sacrificial hydrogen acceptor. The strategy enabled the synthesis of 3-aryl benzofurans in good to excellent yields.

SUBMITTER: Aggarwal S

PROVIDER: S-EPMC9054549 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans.

Aggarwal Sakshi S Srinivas Dasari D Sreenivasulu Chinnabattigalla C Satyanarayana Gedu G

RSC advances 20200610 37

Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. Notably, simple O2 gas served as an oxidant, without using any sacrificial hydrogen acceptor. The strategy enabled the synthesis of 3-aryl benzofurans in good to excellent yields. ...[more]

PMID: 35516592

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