Proline derived guanidine catalysts forge extensive H-bonded architectures: a solution and solid state study.

ABSTRACT: The preparation of a range of amino acid derived guanidine organocatalysts is reported together with their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 56%. Some insight into the mechanism was sought by using X-ray crystallography and a detailed study of the intra- and intermolecular hydrogen bonding is reported.

SUBMITTER: Al-Taie ZS 

PROVIDER: S-EPMC9054603 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature