Effects of lipid membrane composition on the distribution of biocidal guanidine oligomer with solid supported lipid membranes.

ABSTRACT: Polyhexamethylene guanidine (PHMG) is a cationic antimicrobial oligomer that has been used prevalently over the past few decades. However, due to the lack of inhalation toxicity assessment of PHMG, it has caused severe health damage, including fatal lung fibrosis, after being used as one of the major active ingredients of humidifier disinfectants in Korea. Because the first step of the entry of PHMG into airway is its association with cell membranes, the distribution of PHMG between lipid membranes and water is very important to know the depositional flux in the respiratory systems and related toxic mechanisms. We developed a quantitative method to determine the distribution constant (K _lipw) of PHMG between solid supported lipid membranes and water and evaluated the effe

SUBMITTER: Ha Y 

PROVIDER: S-EPMC9054620 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature