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Development of a flexible, sweat-based neuropeptide Y detection platform.


ABSTRACT: Neuropeptide Y (NPY) biomarker levels have a close association with the diagnosis of Major Depression Disorder (MDD) and anxiety disorders. Quantifying NPY in correlation to self-reported symptoms will be an important measure to ensure a relatively uniform diagnosis and help with disease prognosis of these disorders. The work presented is a novel, passive eccrine sweat based, electrochemical detection platform for quantification of NPY biomarker levels. The paper offers a comparison between non-porous and porous sensor platforms using various electrochemical detection techniques. This work uses a novel strategy towards designing an optimal nanobioelectronic interface to measure NPY. The portability aspect of this detection platform is discussed by the demonstration a novel, portable EmStat Pico based electronic platform. The detection limit of the sensor is 10 pg mL-1 and its range is 20-500 pg mL-1. The NPY detection platform is envisioned to be a wearable point-of need monitoring system for management of chronic anxiety disorders and MDD.

SUBMITTER: Mintah Churcher NK 

PROVIDER: S-EPMC9054693 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Development of a flexible, sweat-based neuropeptide Y detection platform.

Mintah Churcher Nathan Kodjo NK   Upasham Sayali S   Rice Paul P   Bhadsavle Serena S   Prasad Shalini S  

RSC advances 20200617 39


Neuropeptide Y (NPY) biomarker levels have a close association with the diagnosis of Major Depression Disorder (MDD) and anxiety disorders. Quantifying NPY in correlation to self-reported symptoms will be an important measure to ensure a relatively uniform diagnosis and help with disease prognosis of these disorders. The work presented is a novel, passive eccrine sweat based, electrochemical detection platform for quantification of NPY biomarker levels. The paper offers a comparison between non-  ...[more]

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