Foregut organ progenitors and their niche display distinct viscoelastic properties in vivo during early morphogenesis stages.

ABSTRACT: Material properties of living matter play an important role for biological function and development. Yet, quantification of material properties of internal organs in vivo, without causing physiological damage, remains challenging. Here, we present a non-invasive approach based on modified optical tweezers for quantifying sub-cellular material properties deep inside living zebrafish embryos. Material properties of cells within the foregut region are quantified as deep as 150 µm into the biological tissue through measurements of the positions of an inert tracer. This yields an exponent, α, which characterizes the scaling behavior of the positional power spectra and the complex shear moduli. The measurements demonstrate differential mechanical properties: at the time when the developing organ

SUBMITTER: Dzementsei A 

PROVIDER: S-EPMC9054744 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature